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How is the concentration of drugs in human plasma defined?


Some drugs bind extensively to plasma proteins (Warfarin binds 99%) whereas others have virtually no binding.

Extraction depends on the type of drug - there are different standard techniques for acidic, basic, and neutral drugs - and, indeed, some drugs need specific extraction techniques.

It is important for you doing bioequivalence studies to know exactly the proportion of drug extracted but such controls are again specific for each drug and use specific marker compounds.

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Why is buprenorphine less addictive than other opioids (like fentanyl) - is it explainable by its strength of binding to the common receptor, or?How is the calculation derived for a drug to be bioequivalent with other? On which base the limit is fixed as 80-120% for a drug to be bioequivalent. What is meant by 90% confidential interval?