Biotechnology Question:
Download Questions PDF

How is the calculation derived for a drug to be bioequivalent with other? On which base the limit is fixed as 80-120% for a drug to be bioequivalent. What is meant by 90% confidential interval?

Answer:

To be "bioequivalent" two preparations or drugs need to give the same biological effect.

The usual "experimental error" put on this is 20% - thus, 80-120% is considered "bioequivalent.”

90 percentage confidence interval means that statistically it is 90% certain that the results are equivalent.

Download Biotechnology Interview Questions And Answers PDF

Previous QuestionNext Question
How is the concentration of drugs in human plasma defined?When we do liquid extraction, what is the effect of adding 10%acid or any base and how do we know which has to be added and up to which concentration or micro liter level can we add such buffers? If any gel formation occurs at the time of extraction, how will it affect the analysis? Shall we continue the extraction with the same or should we drop that method?