Bio Chemistry Question:
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Is it expected a change in the primary, in the secondary or in the tertiary structure of a protein to produce more functional consequences?

Answer:

Any change of the protein structure is relevant if it alters its biological activity. Changes in the primary protein structure are more important because they are modifications in the composition of the molecule and such composition determines all other structures of the protein.

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What are some factors that can lead to protein denaturizing?In sickle cell anemia, a hereditary disease, there is substitution of one amino acid by other in one of the four-polypeptide chains of hemoglobin. In this case, are all of the structural levels of the protein modified?